DRP1 Antibody [Biotin]

Novus Biologicals, part of Bio-Techne | Catalog # NB110-55288B

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NB110-55288AF350

Alexa Fluor 405

NB110-55288AF405

Alexa Fluor 488

NB110-55288AF488

Alexa Fluor 532

NB110-55288AF532

Alexa Fluor 594

NB110-55288AF594

Alexa Fluor 647

NB110-55288AF647

Alexa Fluor 700

NB110-55288AF700

Alexa Fluor 750

NB110-55288AF750

Allophycocyanin

NB110-55288APC

CoraFluor 1

NB110-55288CL1

DyLight 350

NB110-55288UV

DyLight 405

NB110-55288V

DyLight 488

NB110-55288G

DyLight 550

NB110-55288R

DyLight 594

NB110-55288DL594

DyLight 650

NB110-55288C

DyLight 680

NB110-55288FR

DyLight 755

NB110-55288IR

FITC

NB110-55288F

HRP

NB110-55288H

Janelia Fluor 525

NB110-55288JF525

Janelia Fluor 549

NB110-55288JF549

Janelia Fluor 585

NB110-55288JF585

Janelia Fluor 635

NB110-55288JF635

Janelia Fluor 646

NB110-55288JF646

Janelia Fluor 669

NB110-55288JF669

mFluor Violet 450 SE

NB110-55288MFV450

mFluor Violet 500 SE

NB110-55288MFV500

mFluor Violet 610 SE

NB110-55288MFV610

PE

NB110-55288PE

PerCP

NB110-55288PCP

Forumulation

Catalog #

BSA Free

NB110-55288

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Fish, Primate

Predicted:

Bovine (100%). Backed by our 100% Guarantee.

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Simple Western, Western Blot

Label

Biotin

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all DRP1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide made to an internal region within residues 500-600 of the human DRP1 protein. [Swiss-Prot# O00429]

Reactivity Notes

Use in Rat reported in scientific literature (PMID:34622072). Fish reactivity reported in scientific literature (PMID: 25008790).

Localization

Cytoplasm; cytosol. Intracytoplasmic membrane; peripheral mambrane protein. Mainly cytosolic. Also membrane-associated. Localizes to mitochondia at spots of division events. Associated with peroxisomal membranes, it is recruited in part by PEX11B.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for DRP1 Antibody [Biotin]

Application

Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Simple Western

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: DRP1

DRP1 (dynamin-related protein 1) is a highly conserved large GTPase protein which implicates in several important structural features of mitochondria, including mitochondrial shape, size, distribution, remodeling and maintenance. It functions in mitochondrial as well as peroxisomal division, and facilitates membrane fission via oligomerization into ring-like structures that wrap around fission site to constrict/split the membranes through a GTP hydrolysis-dependent mechanism. For normal brain development, DRP1 plays an essential role by mediating developmentally-regulated apoptosis during neural tube development. It is also required for a normal rate of cytochrome c release or caspase activation during apoptosis and for mitochondrial fission during mitosis, programmed necrosis execution and also for vesicle transport. Moreover, it is associated with mitochondrial structural and functional alterations such as fragmentation, phosphorylation, SUMOylation, ubiquitination and cell death. Drp1 interacts with amyloid beta, causing abnormal mitochondrial dynamics and neuronal damage in Alzheimer's disease patients, and defective DRP1 is also linked to encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF).

Long Name

Dynamin-1-like protein

Alternate Names

DLP1, DNM1L, DVLP, Dymple, HdynIV

Gene Symbol

DNM1L

Additional DRP1 Products

Product Documents for DRP1 Antibody [Biotin]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for DRP1 Antibody [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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