DUSP14 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-887

Novus Biologicals, part of Bio-Techne
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NB100-887
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all DUSP14 Antibodies »

Product Specifications

Immunogen

Peptide with sequence CEKESRHLMPYWGI corresponding to C-Terminus according to NP_008957.1.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for DUSP14 Antibody

Immunohistochemistry-Paraffin: DUSP14 Antibody [NB100-887]

Immunohistochemistry-Paraffin: DUSP14 Antibody [NB100-887]

Immunohistochemistry-Paraffin: DUSP14 Antibody [NB100-887] - Staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for DUSP14 Antibody

Application
Recommended Usage

Immunohistochemistry

3.5 ug/ml

Immunohistochemistry-Paraffin

3.5 ug/ml

Peptide ELISA

Detection limit 1:32000

Western Blot

1 ug/ml
Application Notes
WB: No signal obtained yet ,but low background observed in human liver extracts at up to 1 ug/ml. IHC: Paraffin embedded Human Testis.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: DUSP14

In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 which interacts with B7-1 and B7-2 ligands on antigen-presenting cells. CD28 co stimulation induces transcription of interleukin-2 and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK and JNK, and the subsequent creation of AP1 transcription factor. DUSP14 is a negative regulator of CD28 signaling.

Alternate Names

dual specificity phosphatase 14, EC 3.1.3.16, EC 3.1.3.48, MAP kinase phosphatase 6, Mitogen-activated protein kinase phosphatase 6, MKP-1 like protein tyrosine phosphatase, MKP-1-like protein tyrosine phosphatase, MKP-6, MKP6MKP-Ldual specificity protein phosphatase 14

Entrez Gene IDs

11072 (Human); 56405 (Mouse)

Gene Symbol

DUSP14

UniProt

NP_008957. (Human)

Additional DUSP14 Products

Product Documents for DUSP14 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for DUSP14 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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