Dynamin Antibody (SR2307)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21813

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21813-100ul
NBP3-21813-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2307

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Dynamin Antibodies »

Product Summary for Dynamin Antibody (SR2307)

Immunogen

A synthesized peptide derived from human Dynamin (Uniprot #: Q05193)

Specificity

Detects endogenous levels of total Dynamin

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

97 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Dynamin Antibody (SR2307)

Western Blot: Dynamin Antibody (SR2307) [NBP3-21813] -

Western Blot: Dynamin Antibody (SR2307) [NBP3-21813] - Western blot analysis using NBP3-21813 in (1) SH-SY5Y cell lysate; (2) NIH/3T3 cell lysate.

Applications for Dynamin Antibody (SR2307)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Dynamin

The dynamin family of GTPases is essential for receptor-mediated endocytosis and synaptic vesicle recycling, and it has recently been shown to play a role in vesicle formation from the trans-Golgi network (1). Dynamin-1 is a GTP-, microtubule-, and phospholipid-binding protein that is expressed primarily in brain and almost exclusively expressed in the central nervous system (2). Dynamin-1 is believed to assemble around the necks of clathrin-coated pits and assist in pinching vesicles from the plasma membrane. This role would make dynamin unique among GTPases in its ability to act as a mechanochemical enzyme (1). Dynamin-1 function is apparently essential for scission of newly formed vesicles from the plasma membrane; it has been proposed that dynamin is a regulator of downstream effectors of scission, rather than being directly responsible for it (3).

Alternate Names

DNM1

Gene Symbol

DNM1

Additional Dynamin Products

Product Documents for Dynamin Antibody (SR2307)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Dynamin Antibody (SR2307)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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