DYRK1A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-84032

Novus Biologicals, part of Bio-Techne
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NBP1-84032
NBP1-84032-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all DYRK1A Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: VRQQFPAPLGWSGTEAPTQVTVETHPVQETTFHVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQDSMEVGHSHHSMTSLSSSTTSSSTSSSSTG

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DYRK1A Antibody

Western Blot: DYRK1A Antibody [NBP1-84032]

Western Blot: DYRK1A Antibody [NBP1-84032]

Western Blot: DYRK1A Antibody [NBP1-84032] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp
Immunohistochemistry-Paraffin: DYRK1A Antibody [NBP1-84032]

Immunohistochemistry-Paraffin: DYRK1A Antibody [NBP1-84032]

Immunohistochemistry-Paraffin: DYRK1A Antibody [NBP1-84032] - Staining of human liver shows no positivity in hepatocytes as expected.
Immunohistochemistry-Paraffin: DYRK1A Antibody [NBP1-84032]

Immunohistochemistry-Paraffin: DYRK1A Antibody [NBP1-84032]

Immunohistochemistry-Paraffin: DYRK1A Antibody [NBP1-84032] - Staining of human placenta shows moderate to strong cytoplasmic positivity in trophoblastic cells.
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Applications for DYRK1A Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DYRK1A

DYRK1A encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

Long Name

Dual-specificity Tyrosine-[Y]-phosphorylation Regulated Kinase 1A

Alternate Names

MNBH

Entrez Gene IDs

1859 (Human)

Gene Symbol

DYRK1A

UniProt

Q13627

Additional DYRK1A Products

Product Documents for DYRK1A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for DYRK1A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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