DYRK1A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-30799

Novus Biologicals, part of Bio-Techne
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NBP3-30799-100ug
NBP3-30799-25ug
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Sheep IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all DYRK1A Antibodies »

Product Specifications

Immunogen

Sheep were immunized with a recombinant protein corresponding to amino acids 486 to 763 of the mouse DYRK1Aprotein.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Scientific Data Images for DYRK1A Antibody

DYRK1A Antibody

Immunoprecipitation: DYRK1A Antibody [NBP3-30799] -

Immunoprecipitation: DYRK1A Antibody [NBP3-30799] - Immunoprecipitation ofDyrk from 293T transfected cells. Immunoprecipitation with- 1) control Ab, 2)Anti-MNP 2 ug/ml, 3)Novus Biologicals' anti-Dyrk 2ug/ml, 4) Novus Biologicals'-Dyrk 10 ug/ml, 5)competitor’s anti-Dyrk Ab 10 ug/ml, Western blot performed with Novus Biologicals' anti-Dyrk Ab at 2 ug/ml.

Applications for DYRK1A Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

: 1-10 ug/ml

Western Blot

: 1 ug/ml
Application Notes
.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Ammonium sulfate precipitation

Formulation

Phosphate buffered saline

Preservative

0.08% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: DYRK1A

DYRK1A encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

Long Name

Dual-specificity Tyrosine-[Y]-phosphorylation Regulated Kinase 1A

Alternate Names

MNBH

Gene Symbol

DYRK1A

Additional DYRK1A Products

Product Documents for DYRK1A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for DYRK1A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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