E2F6 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-46117

Novus Biologicals, part of Bio-Techne
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NBP1-46117
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all E2F6 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-NPQQSEELLEVSN corresponding to C-Terminus according to NP_937987.2.

Epitope

C-terminus

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for E2F6 Antibody

Western Blot: E2F6 Antibody [NBP1-46117]

Western Blot: E2F6 Antibody [NBP1-46117]

Western Blot: E2F6 Antibody [NBP1-46117] - NBP1-46117 (1ug/ml) staining of Human Skeletal Muscle lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for E2F6 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:4000

Western Blot

1 - 3 ug/ml
Application Notes
WB: Approx. 33 kDa band observed in human skeletal muscle lysates (calculated MW of 31.8 kDa band according to NP_937987.2).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: E2F6

This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.

Alternate Names

E2F transcription factor 6, E2F-6MGC111545, transcription factor E2F6

Entrez Gene IDs

1876 (Human)

Gene Symbol

E2F6

UniProt

NP_937987.2 (Human)

Additional E2F6 Products

Product Documents for E2F6 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for E2F6 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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