E6AP/UBE3A Antibody (SR1023)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21827

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21827-100ul
NBP3-21827-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1023

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all E6AP/UBE3A Antibodies »

Product Summary for E6AP/UBE3A Antibody (SR1023)

Immunogen

A synthesized peptide derived from human E6AP/UBE3A (Uniprot #: Q05086)

Specificity

Detects endogenous levels of total E6AP/UBE3A

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

100 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for E6AP/UBE3A Antibody (SR1023)

Western Blot: E6AP/UBE3A Antibody (SR1023) [NBP3-21827] -

Western Blot: E6AP/UBE3A Antibody (SR1023) [NBP3-21827] - Western blot analysis using NBP3-21827 in K562 cell lysate.

Applications for E6AP/UBE3A Antibody (SR1023)

Application
Recommended Usage

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: E6AP/UBE3A

UBE3A encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

Long Name

Human Papillomavirus E6-associated Protein

Alternate Names

ANCR, EPVE6AP, HPVE6A, UBE3A

Gene Symbol

UBE3A

Additional E6AP/UBE3A Products

Product Documents for E6AP/UBE3A Antibody (SR1023)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for E6AP/UBE3A Antibody (SR1023)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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