EAAT2/GLT1 Antibody (SR2082)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21735

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21735-100ul
NBP3-21735-50ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2082

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all EAAT2/GLT1 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human EAAT2/GLT1 (Uniprot #: P43004)

Specificity

Detects endogenous levels of total EAAT2/GLT1

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

62 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for EAAT2/GLT1 Antibody (SR2082)

Western Blot: EAAT2/GLT1 Antibody (SR2082) [NBP3-21735] -

Western Blot: EAAT2/GLT1 Antibody (SR2082) [NBP3-21735] - Western blot analysis using NBP3-21735 in HeLa cell lysate.

Applications for EAAT2/GLT1 Antibody (SR2082)

Application
Recommended Usage

Immunoprecipitation

1:50

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: EAAT2/GLT1

GLT1 is the major glial glutamate transporter that takes up more than 90% of glutamate from the synapse. GLT1b is a splice variant that contains 11 unique amino acids at the C-terminus that encode a PDZ binding domain. GLT1b was initially believed to be the neuronal isoform of GLT1, but it now appears that GLT1b is localized to astrocytes in the normal brain and to neurons in pathological conditions. In Lou Gehrig's Disease, GLT1a is decreased, while GLT1b is increased. There are also different expressions in hypoxic cells, which have not yet been fully elucidated.

Long Name

Excitatory Amino Acid Transporter 2

Alternate Names

EAAT2, GLT1, SLC1A2

Gene Symbol

SLC1A2

Additional EAAT2/GLT1 Products

Product Documents for EAAT2/GLT1 Antibody (SR2082)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for EAAT2/GLT1 Antibody (SR2082)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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