EAAT3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-17050

Novus Biologicals, part of Bio-Techne
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NBP3-17050-100ul
NBP3-17050-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (97%), Rat (96%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all EAAT3 Antibodies »

Product Summary for EAAT3 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: FGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQ

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for EAAT3 Antibody

Immunocytochemistry/ Immunofluorescence: EAAT3 Antibody [NBP3-17050]

Immunocytochemistry/ Immunofluorescence: EAAT3 Antibody [NBP3-17050]

Immunocytochemistry/Immunofluorescence: EAAT3 Antibody [NBP3-17050] - Analysis in human small intestine and testis tissues using Anti-SLC1A1 antibody. Corresponding SLC1A1 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: EAAT3 Antibody [NBP3-17050]

Immunohistochemistry-Paraffin: EAAT3 Antibody [NBP3-17050]

Immunohistochemistry-Paraffin: EAAT3 Antibody [NBP3-17050] - Staining of human small intestine shows high expression.
Immunohistochemistry-Paraffin: EAAT3 Antibody [NBP3-17050]

Immunohistochemistry-Paraffin: EAAT3 Antibody [NBP3-17050]

Immunohistochemistry-Paraffin: EAAT3 Antibody [NBP3-17050] - Staining of human testis shows low expression as expected.

Applications for EAAT3 Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: EAAT3

The EAAT3 gene encodes for glutamate transporters (also known as excitatory amino acid transporters, EAATs), that rapidly move glutamate from the postsynaptic cleft through the plasma membrane. The proteins are approximately 542 amino acids long at a mass barely over 57 kDA. This function allows for neurotoxic levels of glutamate in the brain to be avoided. It is common to see underactivity of glutamate receptors in some disorders such as ischemia and traumatic brain injuries and overactivity to be linked to mental illnesses such as schizophrenia. EAAT3 gene is also related to obsessive-compulsive disorder, ganglioglioma, autism spectrum disorders, aminoaciduriam temporal lobe epilepsy, hepatic encephalopathy, neuronitis, anorexia nervosa, and amyotrophic lateral sclerosis. It interacts with KNCN, HCCS, EWSR1, PRKCA, and ARL6IP5 to function in pathways of glutamic acid signaling, transmembrane transport of small molecules, and protein digestion and absorption.

Long Name

Excitatory amino acid transporter 3

Alternate Names

EAAC1, SLC1A1

Gene Symbol

SLC1A1

Additional EAAT3 Products

Product Documents for EAAT3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for EAAT3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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