Embigin/EMB Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-24689

Novus Biologicals, part of Bio-Techne
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NBP2-24689
NBP2-24689SS
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all Embigin/EMB Antibodies »

Product Specifications

Immunogen

A portion of amino acids 130-180 of human Embigin was used as the immunogen for this antibody.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Embigin/EMB Antibody

Western Blot: Embigin/EMB Antibody [NBP2-24689]

Western Blot: Embigin/EMB Antibody [NBP2-24689]

Western Blot: Embigin/EMB Antibody [NBP2-24689] - Analysis of Embigin/EMB in MCF7 lysate in the 1) absence and 2) presence of immunizing peptide and 3) RAW lysate using Embigin/EMB antibody at 0.25 ug/ml.

Applications for Embigin/EMB Antibody

Application
Recommended Usage

Western Blot

0.25-2 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Embigin/EMB

Embigin (EMB) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily (IgSF) proteins. It is a cell adhesion molecule that is preferentially expressed during mouse embryogenesis (1). Embigin, along with basigin and neuroplastin, form a small subgroup within the IgSF, with all members possessing a glutamate at the same position in the transmembrane domain (2). Mature, human Embigin is highly glycosylated and consists of an extracellular domain (ECD) wjth two Ig domains, a transmembrane region, and a short intracellular region. Within the ECD, human EMB shares 75% and 62% amino acid identity with mouse and rat EMB, respectively. Embigin is an accessory protein of monocarboxylic acid transporter, MCT2 which participates in transporting lactic acid between glial cells and neurons (3). Thus, it may be related to brain energy metabolism and has been investigated as a susceptible gene for schizophrenia (4). Embigin is highly expressed in early embryos of mice, and in the heart, lung, brain and other tissues of adult rats (5, 6). Loss of embigin promotes proliferation, anchorage-independent growth, and migration ability of breast cancer cells (7).

Alternate Names

EMB, GP70

Gene Symbol

EMB

UniProt

Q6PCB8 (Human)

Additional Embigin/EMB Products

Product Documents for Embigin/EMB Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Embigin/EMB Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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