EMMPRIN/CD147 Antibody (BSG/963)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-44537

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # BSG/963

Concentration

0.2 mg/ml

View all EMMPRIN/CD147 Antibodies »

Product Specifications

Immunogen

Recombinant human EMMPRIN/CD147 protein (Uniprot: P35613)

Localization

Cell surface

Specificity

This monoclonal antibody recognizes extracellular epitope of human CD147. It is expressed more intensely on thymocytes than on mature peripheral blood T cells. CD147 is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. It stimulates the production of interstitial collagenase, gelatinase A, stromelysin-1 and various metalloproteinases (MMPs) by fibroblasts. These enzymes are important factors in cancer invasion and metastasis.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Description

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP3-11531)

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.

Scientific Data Images for EMMPRIN/CD147 Antibody (BSG/963)

Immunohistochemistry-Paraffin: EMMPRIN/CD147 Antibody (BSG/963) [NBP2-44537]

Immunohistochemistry-Paraffin: EMMPRIN/CD147 Antibody (BSG/963) [NBP2-44537]

Immunohistochemistry-Paraffin: EMMPRIN/CD147 Antibody (BSG/963) [NBP2-44537] - Human Testicular Carcinoma stained with CD147 Monoclonal Antibody (BSG/963).
Immunohistochemistry-Paraffin: EMMPRIN/CD147 Antibody (BSG/963) [NBP2-44537]

Immunohistochemistry-Paraffin: EMMPRIN/CD147 Antibody (BSG/963) [NBP2-44537]

Immunohistochemistry-Paraffin: EMMPRIN/CD147 Antibody (BSG/963) [NBP2-44537] - Human Colon Carcinoma stained with CD147 Monoclonal Antibody (BSG/963).
Immunohistochemistry-Paraffin: EMMPRIN/CD147 Antibody (BSG/963) [NBP2-44537]

Immunohistochemistry-Paraffin: EMMPRIN/CD147 Antibody (BSG/963) [NBP2-44537]

Immunohistochemistry-Paraffin: EMMPRIN/CD147 Antibody (BSG/963) [NBP2-44537] - Human Renal Cell Carcinoma stained with CD147 Monoclonal Antibody (BSG/963).

Applications for EMMPRIN/CD147 Antibody (BSG/963)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2 ug/ml
Application Notes
Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 minutes at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes.
Optimal dilution for a specific application should be determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: EMMPRIN/CD147

CD147 plays a pivotal role in spermatogenesis, embryo implantation, neural network formation and tumor progression. It stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). CD147 may target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. CD147 also seems to be a receptor for oligomannosidic glycans. In vitro, it promotes outgrowth of astrocytic processes. CD147 forms homooligomers in a cis-dependent manner on the plasma membrane. It forms a complex with MMP1 at the tumor cell surface. CD147 interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. CD147 also interacts with ATP1B2, MAG and L1CAM.

Long Name

Extracellular Matrix Metalloproteinase Inducer

Alternate Names

Basigin, BSG, CD147

Gene Symbol

BSG

UniProt

P35613 (Human)

Additional EMMPRIN/CD147 Products

Product Documents for EMMPRIN/CD147 Antibody (BSG/963)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for EMMPRIN/CD147 Antibody (BSG/963)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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