ERR beta/NR3B2 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS7131

Novus Biologicals, part of Bio-Techne
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NLS7131
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Porcine, Bovine, Canine, Equine, Hamster, Monkey, Primate, Rabbit

Cited:

Mouse

Predicted:

Avian (93%), Chicken (93%), Rat (93%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all ERR beta/NR3B2 Antibodies »

Product Specifications

Immunogen

Synthetic 15 amino acid peptide from ligand-binding domain of human ERR beta/NR3B2.

Epitope

Ligand-binding domain

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 18472334). Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Bat (87%), Zebrafish (80%).

Specificity

Human ESRRB. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ESRRG (67%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for ERR beta/NR3B2 Antibody - BSA Free

Immunohistochemistry-Paraffin: ERR beta/NR3B2 Antibody - BSA Free [NLS7131]

Immunohistochemistry-Paraffin: ERR beta/NR3B2 Antibody - BSA Free [NLS7131]

Immunohistochemistry-Paraffin: ERR beta/NR3B2 Antibody [NLS7131] - Colon, Carcinoma
Immunohistochemistry-Paraffin: ERR beta/NR3B2 Antibody - BSA Free [NLS7131]

Immunohistochemistry-Paraffin: ERR beta/NR3B2 Antibody - BSA Free [NLS7131]

Immunohistochemistry-Paraffin: ERR beta/NR3B2 Antibody [NLS7131] - Human testis tissue after heat-induced antigen retrieval.
Immunohistochemistry-Paraffin: ERR beta/NR3B2 Antibody - BSA Free [NLS7131]

Immunohistochemistry-Paraffin: ERR beta/NR3B2 Antibody - BSA Free [NLS7131]

Immunohistochemistry-Paraffin: ERR beta/NR3B2 Antibody [NLS7131] - Analysis of anti-ESRRB / ERR Beta antibody with human lung, small cell carcinoma.
View 1 more images

Applications for ERR beta/NR3B2 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

3 ug/ml
Application Notes
.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: ERR beta/NR3B2

Estrogen-related receptor beta (ERR beta) a NR3 Steroid Receptor, has been shown to affect early placental development. ERR beta also can act as a repressor of transcriptional activity mediated by the glucocorticoid receptor (GR). ERR beta binds as a monomer to the extended half-site TNAAGTGCA and as a homodimer to the estrogen response element (ERE), palindromic thyroid hormone response element (TRE(pal)), and SF-1 response element, but not to the glucocorticoid response element (GRE). ERR beta mutations lead to abnormal development of the chorion and defective diploid trophoblast proliferation, and are lethal during midgestation. ERR beta expression has been documented in mice in the extraembryonic ectoderm that gives rise to the chorion. ESTs have been isolated from normal human eye, lung, and testis libraries.

Long Name

Estrogen-related Receptor beta

Alternate Names

ERR2, ESRL2, ESRRB, NR3B2

Entrez Gene IDs

2103 (Human)

Gene Symbol

ESRRB

Additional ERR beta/NR3B2 Products

Product Documents for ERR beta/NR3B2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for ERR beta/NR3B2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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