Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # OTI1H5

Concentration

1 mg/ml

View all Factor XII heavy chain Antibodies »

Product Specifications

Immunogen

Human recombinant protein fragment corresponding to amino acids 73-372 of human F12(NP_000496) produced in E.coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Factor XII heavy chain Antibody (OTI1H5)

Immunohistochemistry-Paraffin: Factor XII heavy chain Antibody (OTI1H5) [NBP2-45561]

Immunohistochemistry-Paraffin: Factor XII heavy chain Antibody (OTI1H5) [NBP2-45561]

Immunohistochemistry-Paraffin: Factor XII heavy chain Antibody (OTI1H5) [NBP2-45561] - Staining of paraffin-embedded Carcinoma of Human liver tissue using anti-F12 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: Factor XII heavy chain Antibody (OTI1H5) [NBP2-45561]

Immunohistochemistry-Paraffin: Factor XII heavy chain Antibody (OTI1H5) [NBP2-45561]

Immunohistochemistry-Paraffin: Factor XII heavy chain Antibody (OTI1H5) [NBP2-45561] - Staining of paraffin-embedded Human liver tissue using anti-F12 mouse monoclonal antibody.

Applications for Factor XII heavy chain Antibody (OTI1H5)

Application
Recommended Usage

Immunohistochemistry

1:150

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Factor XII heavy chain

The F12 gene encodes a 615 amino acid long, 67 kDA serum glycoprotein coagulation factor XII that is eventually cleaved into four chains. Factor XII functions in the initiation of blood coagulation, fibrinolysis, as well as in the creation of bradykinin and angiotension. F12 participates in cell adhesion plasmin signaling, blood coagulation signaling pathways, MSP-RON signaling, intrinsic prothrombin activation pathways, and blood clotting cascades. It interacts with Genes CD93, MMP13, EPAS1, APP, and KLKB1. Defects in F12 lead to factor Xii deficiency (Hageman factor deficiency) as well as hereditary angioedema type 3 (estrogen-related HAE). F12 is also associated with blood clots, acute myocardial infarction, thrombosis, spastic paraplegia, angiodema, retinal vein occlusion, arterial calcification, heart disease, C1 inhibitor deficiency, hemorrhagic disease, and acalculous cholecystitis.

Alternate Names

beta-factor XIIa part 1, coagulation factor XII, coagulation factor XII (Hageman factor), coagulation factor XIIa heavy chain, coagulation factor XIIa light chain, EC 3.4.21, EC 3.4.21.38, HAE3, HAEX, HAFbeta-factor XIIa part 2, Hageman factor

Gene Symbol

F12

Additional Factor XII heavy chain Products

Product Documents for Factor XII heavy chain Antibody (OTI1H5)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Factor XII heavy chain Antibody (OTI1H5)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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