Fibronectin Antibody (DH1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-51723

Novus Biologicals, part of Bio-Techne
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NBP1-51723
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Key Product Details

Species Reactivity

Validated:

Human, Rat, Chicken, Guinea Pig, Rabbit

Cited:

Human

Applications

Validated:

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # DH1

Concentration

0.1 mg/ml

View all Fibronectin Antibodies »

Product Specifications

Immunogen

Purified fibronectin from A8387 fibrosarcoma cells

Specificity

The antibody is specific to extradomain A (EDA) sequence of a cellular fibronectin and recognizes thus only the cellular fibronectin

Marker

Mesenchymal Cells Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Fibronectin Antibody (DH1)

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Western Blot

1:100-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS, 1% BSA

Preservative

0.1% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Fibronectin

Integrin beta1 also known as integrin VLA-4 beta chain, fibronectin receptor beta chain, and CD29) is a 130 kD integrin beta chain containing VWFA-like domains. Five isoforms have been reported (beta1A-1D, 1C-2). This Type I membrane protein is a subunit of the heterodimeric receptor for laminin, fibronectin, collagen, fibrinogen, VCAM1, cytotactin, osteopontin, epiligrin, thrombospondin, and vitronectin. Signal transduction through the integrins affects embryogenesis, hemostasis, tissue repair, immune response, and metastatic spread of tumor cells. Integrin beta1 can be upregulated by LPS with soluble CD14 and TNF-alpha; downregulation of integrin beta1 by alpha-melanocyte stimulating hormone and progesterone. Integrin beta1 is modified by phosphorylation and glycosylation. Integrin beta1 partners with integrin alpha subunits alphav, and alpha1 through alpha1.1. The Poly6004 antibody recognizes the N-terminal region of human integrin beta1 and has been shown to be useful for Western blotting. Partners with integrin alpha subunits alphav, alpha1 through alpha11.

Alternate Names

CIG, ED-B, FINC, FN1, FNZ, GFND2, LETS, SMDCF

Gene Symbol

FN1

Additional Fibronectin Products

Product Documents for Fibronectin Antibody (DH1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Fibronectin Antibody (DH1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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