FoxP3 Antibody (03) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21485

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21485
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Mouse IgG2A Clone # 03

Format

Azide and BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all FoxP3 Antibodies »

Product Specifications

Immunogen

This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, a synthetic peptide corresponding to the center region of the human FoxP3.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for FoxP3 Antibody (03) - Azide and BSA Free

FoxP3 Antibody (03)

IHC-P-NBP3-21485-FoxP3 Antibody (03)-

IHC-P-NBP3-21485-FoxP3 Antibody (03)-Staining of human FOXP3 in human carcinoma of sigmoid with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.
FoxP3 Antibody (03)

IHC-P-NBP3-21485-FoxP3 Antibody (03)-

IHC-P-NBP3-21485-FoxP3 Antibody (03)-Staining of human FOXP3 in human breast carcinoma with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.

Applications for FoxP3 Antibody (03) - Azide and BSA Free

Application
Recommended Usage

Immunohistochemistry

1:100-1:500

Immunohistochemistry-Paraffin

1:100-1:500

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 um filtered solution in PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: FoxP3

Forkhead box P3 (FoxP3), aka Scurfin and JM2, is a protein involving in immune system responses and functioning as a transcriptional regulator crucial in the development and inhibitory of regulatory T-Cells (Treg). FoxP3 is a master regulator of the Treg lineage, who requires Ahr and STAT-5 and other additional transcription factors to retains its complete function and differentiation. Scurfin remains steady and constitutively expressed in two conditions: a high level in CD25 + CD4 positive regulatory T cells and a low level in CD4 positive/CD25 negative cells. JM2 is absent in CD4 negative/CD8 positive T cells. FoxP3 defects are related to various cancers and autoimmune diseases, and X-linked syndrome (IPEX), while overexpression may also cause severe immunodeficiency.

Long Name

Forkhead Box P3

Alternate Names

AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID

Gene Symbol

FOXP3

Additional FoxP3 Products

Product Documents for FoxP3 Antibody (03) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for FoxP3 Antibody (03) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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