Forkhead box P3 (FoxP3), aka Scurfin and JM2, is a protein involving in immune system responses and functioning as a transcriptional regulator crucial in the development and inhibitory of regulatory T-Cells (Treg). FoxP3 is a master regulator of the Treg lineage, who requires Ahr and STAT-5 and other additional transcription factors to retains its complete function and differentiation. Scurfin remains steady and constitutively expressed in two conditions: a high level in CD25 + CD4 positive regulatory T cells and a low level in CD4 positive/CD25 negative cells. JM2 is absent in CD4 negative/CD8 positive T cells. FoxP3 defects are related to various cancers and autoimmune diseases, and X-linked syndrome (IPEX), while overexpression may also cause severe immunodeficiency.

Long Name

Forkhead Box P3

Alternate Names

AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID

Gene Symbol

FOXP3

Additional FoxP3 Products

Product Documents for FoxP3 Antibody (FOXP3/7990R) [DyLight 405]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for FoxP3 Antibody (FOXP3/7990R) [DyLight 405]

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

FoxP3 Antibody (FOXP3/7990R) [DyLight 405]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-20941V

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

Concentration

View all FoxP3 Antibodies »

Product Specifications

Immunogen

Localization

Clonality

Host

Isotype

Applications for FoxP3 Antibody (FOXP3/7990R) [DyLight 405]

Immunohistochemistry-Paraffin

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: FoxP3