GADD153/CHOP Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-49550

Novus Biologicals, part of Bio-Techne
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NBP2-49550
NBP2-49550-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GADD153 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: AESLPFSFGTLSSWELEAWYEDLQEVLSSDENGGTYVSPPGNEEEESKIFTTLDPASLAWLTEEEPEPAEVTSTSQ

Reactivity Notes

Mouse (84%), Rat (88%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GADD153/CHOP Antibody

Immunohistochemistry-Paraffin: GADD153/CHOP Antibody [NBP2-49550]

Immunohistochemistry-Paraffin: GADD153/CHOP Antibody [NBP2-49550]

Immunohistochemistry-Paraffin: GADD153/CHOP Antibody [NBP2-49550] - Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
Immunohistochemistry-Paraffin: GADD153/CHOP Antibody [NBP2-49550]

Immunohistochemistry-Paraffin: GADD153/CHOP Antibody [NBP2-49550]

Immunohistochemistry-Paraffin: GADD153/CHOP Antibody [NBP2-49550] - Staining of human thyroid gland shows moderate to strong nuclear positivity in glandular cells.
Immunohistochemistry-Paraffin: GADD153/CHOP Antibody [NBP2-49550]

Immunohistochemistry-Paraffin: GADD153/CHOP Antibody [NBP2-49550]

Immunohistochemistry-Paraffin: GADD153/CHOP Antibody [NBP2-49550] - Staining of human testis shows moderate to strong nuclear positivity in cells in seminiferous ducts.
View 1 more images

Applications for GADD153/CHOP Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GADD153

GADD153 encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

Long Name

Growth Arrest and DNA Damage-inducible Protein GADD153

Alternate Names

CEBP zeta, CHOP, CHOP10, DDIT3

Gene Symbol

DDIT3

Additional GADD153 Products

Product Documents for GADD153/CHOP Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for GADD153/CHOP Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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