GAT-1/SLC6A1 Antibody (SR2118)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21970

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21970-100ul
NBP3-21970-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR2118

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GAT-1/SLC6A1 Antibodies »

Product Summary for GAT-1/SLC6A1 Antibody (SR2118)

Immunogen

A synthesized peptide derived from human GAT-1/SLC6A1 (Uniprot #: P30531)

Specificity

Detects endogenous levels of total GAT-1/SLC6A1

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

67 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GAT-1/SLC6A1 Antibody (SR2118)

Western Blot: GAT-1/SLC6A1 Antibody (SR2118) [NBP3-21970] -

Western Blot: GAT-1/SLC6A1 Antibody (SR2118) [NBP3-21970] - Western blot analysis using NBP3-21970 in Human fetal brain lysate.

Applications for GAT-1/SLC6A1 Antibody (SR2118)

Application
Recommended Usage

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GAT-1/SLC6A1

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl negative channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003).

Long Name

GABA Transporter 1

Alternate Names

GABATHG, GABATR, GAT1, SLC6A1

Gene Symbol

SLC6A1

Additional GAT-1/SLC6A1 Products

Product Documents for GAT-1/SLC6A1 Antibody (SR2118)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GAT-1/SLC6A1 Antibody (SR2118)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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