Key Product Details

Validated by

Independent Antibodies, Biological Validation

Species Reactivity

Human

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all GCN2 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residues 1 and 50 of human GCN2 (eIF2AK4, eukaryotic translation initiation factor 2 alpha kinase 4) using the numbering given in entry NP_001013725.2 (GeneID 440275).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GCN2 Antibody

Western Blot: GCN2 Antibody [NB100-1593]

Western Blot: GCN2 Antibody [NB100-1593]

Western Blot: GCN2 Antibody [NB100-1593] - Detection of Human GCN2 on HeLa whole cell lysate using NB100-1593. GCN2 was also immunoprecipitated using another GCN2 Ab.

Applications for GCN2 Antibody

Application
Recommended Usage

Immunoprecipitation

2-5 ug/mg lysate

Western Blot

1:5000-1:15000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: GCN2

GCN2 is a kinase that phosphorylates the alpha subunit of EIF2. GCN2 functions as a sensor of amino acid deficiency and modulates protein metabolism in response to cellular stress. GCN2 has also been reported to function in the regulation of lipid metabolism during amino acid deprivation. Alternate names for GCN2 include eukaryotic translation initiation factor 2-alpha kinase 4, GCN2-like protein, EIF2AK4, and KIAA1338.

Long Name

General Control Nonrepressed 2-like Protein

Alternate Names

EIF2AK4

Entrez Gene IDs

440275 (Human)

Gene Symbol

EIF2AK4

UniProt

Q9P2K8

Additional GCN2 Products

Product Documents for GCN2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for GCN2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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