GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (MM0311-3P34) [Janelia Fluor® 646]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-12414JF646

Novus Biologicals, part of Bio-Techne
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NBP2-12414JF646
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Janelia Fluor 646

Antibody Source

Monoclonal Mouse IgG1 Clone # MM0311-3P34

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GFR alpha-4/GDNF R alpha-4 Antibodies »

Product Specifications

Immunogen

Human recombinant GFR alpha-4/GDNF R alpha-4/Persephin receptor

Reactivity Notes

0

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: GFR alpha-4/GDNF R alpha-4

Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFRalpha-1 (previously designated GDNFR-alpha), GFRalpha-2 (also designated RETL2), GFRalpha-3 and GFRalpha-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFRalpha-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands.

Long Name

Glial Cell line-derived Neurotrophic Factor Receptor alpha 4

Alternate Names

GDNF R alpha-4, GFR alpha4, GFRa-4, GFRA4

Gene Symbol

GFRA4

Additional GFR alpha-4/GDNF R alpha-4 Products

Product Documents

Product Datasheets

Certificate of Analysis

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Product Specific Notices



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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