GIPR Antibody (12C6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26553

Recombinant monoclonal antibody expressed in HEK293F cells
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Mouse, Rat

Applications

ELISA

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Mouse IgG2A Clone # 12C6

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GIPR Antibodies »

Product Summary for GIPR Antibody (12C6)

Immunogen

Recombinant Human GIPR protein [UniProt Q0P543]

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for GIPR Antibody (12C6)

GIPR Antibody (12C6)

ELISA: GIPR Antibody (12C6) [NBP3-26553] -

ELISA: GIPR Antibody (12C6) [NBP3-26553] - The Binding Activity of Rat GIPR with GIPR Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Rat GIPR at 2 ug/mL can bind GIPR Antibody, the EC50 is 6.946-8.740 ng/mL.
GIPR Antibody (12C6)

ELISA: GIPR Antibody (12C6) [NBP3-26553] -

ELISA: GIPR Antibody (12C6) [NBP3-26553] - The Binding Activity of Mouse GIPR with GIPR Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse GIPR at 2 ug/mL can bind GIPR Antibody, the EC50 is 8.622-11.36 ng/mL.

Applications for GIPR Antibody (12C6)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50% Glycerol, 0.01M PBS, PH 7.4

Preservative

0.03% Proclin 300

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -70C. Avoid freeze-thaw cycles.

Background: GIPR

GIPR, or Gastric Inhibitory Polypeptide Receptor, mediates GIP-induced secretion of insulin by pancreatic islet beta cells after a meal. GIP is a gastrointestinal peptide hormone of 42 aa that is released from duodenal endocrine K cells after absorption of glucose or fat. Stimulation of the GIPR on pancreatic cells activates adenylyl cyclase and mitogen-activated protein kinase, resulting in increased insulin secretion. Mice with a targeted mutation of GIPR have higher blood glucose levels with impaired initial insulin response after oral glucose load. Analysis of GIPR knockout mice suggest that GIPR defects may contribute to the pathogenesis of diabetes and obesity. Ectopic expression of functional GIPR and its coupling to steroidogenesis has been suggested to be the main cause of food-dependent Cushing's syndrome. Two isoforms of GIPR are produced by alternative splicing. GIPR expression has been reported in human bone, fetal adrenal, and pancreas. Little expression has been identified in normal adult adrenal, but overexpression of GIPR has been observed in the adrenal in food-dependent Cushing's syndrome. GIPR expression has been identified in rat brain, heart, pancreas, and small intestine. ESTs have been isolated from colon libraries.

Long Name

Gastric Inhibitory Polypeptide Receptor

Alternate Names

PGQTL2

Gene Symbol

GIPR

Additional GIPR Products

Product Documents for GIPR Antibody (12C6)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GIPR Antibody (12C6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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