GLP-1R Antibody (HL2298) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-25483

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Mouse

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # HL2298

Format

Azide and BSA Free

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GLP-1R Antibodies »

Product Summary for GLP-1R Antibody (HL2298) - Azide and BSA Free

Immunogen

Synthetic peptide of human GLP-1R.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GLP-1R Antibody (HL2298) - Azide and BSA Free

GLP-1R Antibody (HL2298) - Azide and BSA Free

Western Blot: GLP-1R Antibody (HL2298) - Azide and BSA Free [NBP3-25483] -

Western Blot: GLP-1R Antibody (HL2298) - Azide and BSA Free [NBP3-25483] - Mouse tissue extract (50 ug) was separated by 10% SDS-PAGE, and the membrane was blotted with GLP1R antibody [HL2298] (NBP3-25483) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
GLP-1R Antibody (HL2298) - Azide and BSA Free

Immunohistochemistry-Paraffin: GLP-1R Antibody (HL2298) - Azide and BSA Free [NBP3-25483] -

Immunohistochemistry-Paraffin: GLP-1R Antibody (HL2298) - Azide and BSA Free [NBP3-25483] - GLP1R antibody [HL2298] detects GLP1R protein at cell membrane by immunohistochemical analysis. Sample: Paraffin-embedded mouse pancreas. GLP1R stained by GLP1R antibody [HL2298] (NBP3-25483) diluted at 1:20000. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Applications for GLP-1R Antibody (HL2298) - Azide and BSA Free

Application
Recommended Usage

Western Blot

1:500-1:3000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

Azide and BSA Free

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GLP-1R

GLP1R, a Glucagon Receptor, has been suggested to affect the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. Glucagon-like peptide 1 is an incretin hormone produced by enteroendocrine L-cells in the intestinal mucosa. The hormone is released in response to food intake and plays an important role in maintaining blood glucose homeostasis. Stimulation of the GLP-1R by endogenous hormone induces multiple complementary mechanisms, which together result in a lowering of circulating blood glucose levels. These mechanisms include receptor-mediated enhancement of glucose-induced insulin secretion from pancreatic -cells, inhibition of gastric emptying with a delay in the gastrointestinal resorption of nutrients, inhibition of glucagon secretion, and inhibition of food intake. Desensitization of GLP1R on pancreatic beta-cells is one of the causes of non insulin-dependent diabetes mellitus (NIDDM). GLP1R knockout mice are viable, develop normally, but exhibit increased levels of blood glucose following oral glucose challenge in association with diminished levels of circulating insulin. Recently it has been shown that overexpression of glucagon-like peptide-1 receptor improves learning in rats (During et al. 2003). GLP1R has been reported in pancreas, brain, heart, kidney, lung, and stomach. ESTs have been isolated from kidney and skin libraries.

Long Name

Glucagon-like Peptide 1 Receptor

Alternate Names

GLP1R

Gene Symbol

GLP1R

Additional GLP-1R Products

Product Documents for GLP-1R Antibody (HL2298) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GLP-1R Antibody (HL2298) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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