Glucuronic Acid Epimerase Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-31872

Novus Biologicals, part of Bio-Techne
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NBP2-31872-25ul
NBP2-31872
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Predicted:

Mouse (95%), Rat (94%). Backed by our 100% Guarantee.

Applications

Validated:

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Flow Cytometry, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Glucuronic Acid Epimerase Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: ETSEGVSLQLGNTKDFIISFDLKFLTNGSVSVVLETTEKNQLFTIHYVSNAQLIAFKERDIYYGIGPRTSWSTVTRDLVTDLRKGVGLSNTKAVKPTKIMPKKVVRLI

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Glucuronic Acid Epimerase Antibody

Immunohistochemistry-Paraffin: Glucuronic Acid Epimerase Antibody [NBP2-31872]

Immunohistochemistry-Paraffin: Glucuronic Acid Epimerase Antibody [NBP2-31872]

Immunohistochemistry-Paraffin: Glucuronic Acid Epimerase Antibody [NBP2-31872] - Staining of human cerebral cortex shows cytoplasmic positivity in neuronal cells.

Applications for Glucuronic Acid Epimerase Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Use in Flow and Immunocytochemistry/Immunofluorescence reported in scientific literature (PMID:31972438).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Glucuronic Acid Epimerase

Heparan sulfate (HS) is a negatively charged cell surface polysaccharide required for the biologic activities of circulating extracellular ligands. GLCE is responsible for epimerization of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) of HS, which endows the nascent polysaccharide chain with the ability to bind growth factors and cytokines (Ghiselli and Agrawal, 2005 [PubMed 15853773]).[supplied by OMIM]

Alternate Names

D-glucuronyl C5-epimerase, EC 5.1.3, EC 5.1.3.-, glucuronic acid epimerase, glucuronyl C5-epimerase, Heparin/heparan sulfate:glucuronic acid C5-epimerase, HSEPIheparin/heparan sulfate-glucuronic acid C5-epimerase, KIAA0836heparan sulfate epimerase, UDP-glucuronic acid epimerase

Gene Symbol

GLCE

UniProt

O94923 (Human)

Additional Glucuronic Acid Epimerase Products

Product Documents for Glucuronic Acid Epimerase Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Glucuronic Acid Epimerase Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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