GLUT9 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-06565

Novus Biologicals, part of Bio-Techne
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NBP1-06565
NBP1-06565SS
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Key Product Details

Species Reactivity

Human, Mouse, Primate

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all GLUT9 Antibodies »

Product Specifications

Immunogen

Synthetic peptide made to an internal portion of human GLUT9 (within residues 10-60). [Swiss-Prot# Q9NRM0]

Localization

Membrane (multi-pass membrane protein)

Specificity

This antibody is specific for the human GLUT9 protein Isoform 1 (SLC2A9-L).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

58.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GLUT9 Antibody

Western Blot: GLUT9 Antibody [NBP1-06565]

Western Blot: GLUT9 Antibody [NBP1-06565]

Western Blot: GLUT9 Antibody [NBP1-06565] - Detection of GLUT9a in human kidney membrane prep.
Immunohistochemistry-Paraffin: GLUT9 Antibody [NBP1-06565]

Immunohistochemistry-Paraffin: GLUT9 Antibody [NBP1-06565]

Immunohistochemistry-Paraffin: GLUT9 Antibody [NBP1-06565] - IHC-P analysis mouse kidney section with GLUT9 antibody at 1:200 dilution. This antibody gave the expected staining of SLC2A9-L isoform in the tubular epithelial cells and the blood vessel endothelium.

Applications for GLUT9 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

0.5 ug/ml
Application Notes
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Glycine and 0.15M NaCl

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GLUT9

GLUT9 (glucose transporter 9; SLC2A9) is a multi-pass membrane transporter protein which primarily transport urate and fructose, and may also implicate in urate reabsorption by proximal tubules as well as the transportation of glucose at low rate. GLUT9 belongs to sugar transporter (TC 2.A.1.1) family and SLC2A9 gene encodes two transcripts: a long isoform (GLUT9L/SLC2A9L) and a short isoform (GLUT9S/SLC2A9S). Placenta is one of the few tissues that express both variants suggesting their role in placental hexose transport, and GLUT9 has been shown to transport both glucose and fructose with about 3-fold higher affinity for glucose. GLUT9 has emerged as a high-capacity urate transporter which influences serum uric acid levels; and GLUT9L and GLUT9S isoforms shows strong expression in the basolateral and apical membranes, respectively, of proximal renal tubular cells. GLUT9 is an important modulator responsible for the reabsorption of urate in the apical membrane of the renal proximal tubules, and loss-of-function mutations in GLUT9 gene results in functional impairment associated with renal hypouricemia type 2 (RHUC2), a disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion.

Alternate Names

facilitated glucose transporter member 9, GLUT-9, GLUT9Glut9, GLUTX, solute carrier family 2 (facilitated glucose transporter), member 9, UAQTL2, urate voltage-driven efflux transporter 1

Gene Symbol

SLC2A9

Additional GLUT9 Products

Product Documents for GLUT9 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GLUT9 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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