Glyoxalase II/HAGH Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-99941

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Glyoxalase II Antibodies »

Product Specifications

Immunogen

Produced in rabbits immunized with purified, recombinant Human Glyoxalase II/HAGH (Uniprot#: Q16775-2; Met 1-Asp 260)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

This antibody can be stored at 2C to 8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Avoid repeated freeze-thaw cycles.

Scientific Data Images for Glyoxalase II/HAGH Antibody

Western Blot: Glyoxalase II/HAGH Antibody [NBP2-99941]

Western Blot: Glyoxalase II/HAGH Antibody [NBP2-99941]

Western Blot: Glyoxalase II/HAGH Antibody [NBP2-99941] - Anti-Glyoxalase II/HAGH rabbit polyclonal antibody at 1:500 dilution. Lane A: HepG2 Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary Goat Anti-Rabbit IgG H&L (Dylight 800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 29 kDa. Observed band size: 29 kDa
Immunohistochemistry-Paraffin: Glyoxalase II/HAGH Antibody [NBP2-99941]

Immunohistochemistry-Paraffin: Glyoxalase II/HAGH Antibody [NBP2-99941]

Immunohistochemistry-Paraffin: Glyoxalase II/HAGH Antibody [NBP2-99941] - Immunochemical staining of human Glyoxalase II/HAGH in human liver with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Immunohistochemistry-Paraffin: Glyoxalase II/HAGH Antibody [NBP2-99941]

Immunohistochemistry-Paraffin: Glyoxalase II/HAGH Antibody [NBP2-99941]

Immunohistochemistry-Paraffin: Glyoxalase II/HAGH Antibody [NBP2-99941] - Immunochemical staining of human Glyoxalase II/HAGH in human kidney with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
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Applications for Glyoxalase II/HAGH Antibody

Application
Recommended Usage

ELISA

1:5000-1:10000

Immunohistochemistry-Paraffin

1:500-1:2000

Immunoprecipitation

1-4 uL/mg of lysate

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Antigen and protein A Affinity-purified

Formulation

0.2 um filtered solution in PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Glyoxalase II

HAGH, also known as Hydroxyacylglutathione hydrolase mitochondrial, has a 308 amino acid long isoform that is 34 kDa and located in the mitochondrion matrix and a short 260 amino acid isoform that is 29 kDa and located in the cytoplasm; is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Studies are being performed on the relationship of this protein to glyoxalase ii deficiency, breast carcinoma, carcinoma, familial Mediterranean fever, muscular dystrophy, thrombocytosis, neisseria meningitides, hyperglycemia, bladder carcinoma, alzheimer's disease, prostate cancer, hepatitis b, and prostatitis. HAGH protein involvement has been observed with relation to pyruvate metabolism, secondary metabolite metabolism, methylglyoxal degradation, and (R)-lactate from methylglyoxal pathways where it interacts with MYOC, PRDX2, VPS72, SOD1, and DR1.

Alternate Names

GLX2, HAGH

Gene Symbol

HAGH

Additional Glyoxalase II Products

Product Documents for Glyoxalase II/HAGH Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Glyoxalase II/HAGH Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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