GM2A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-00105

Novus Biologicals, part of Bio-Techne
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NBP3-00105-100ul
NBP3-00105-50ul
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GM2A Antibodies »

Product Specifications

Immunogen

Produced in rabbits immunized with purified, recombinant Human GM2A (Accession#: AAA35907.1; Met1-Ile193)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

This antibody can be stored at 2C to 8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Avoid repeated freeze-thaw cycles.

Scientific Data Images for GM2A Antibody

Immunocytochemistry/ Immunofluorescence: GM2A Antibody [NBP3-00105]

Immunocytochemistry/ Immunofluorescence: GM2A Antibody [NBP3-00105]

Immunocytochemistry/Immunofluorescence: GM2A Antibody [NBP3-00105] - Immunofluorescence staining of GM2A in U251MG cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human GM2A polyclonal antibody (dilution ratio 1:1000) at 4C overnight. Then cells were stained with the Alexa Fluor$488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to cytoplasm.
Immunohistochemistry-Paraffin: GM2A Antibody [NBP3-00105]

Immunohistochemistry-Paraffin: GM2A Antibody [NBP3-00105]

Immunohistochemistry-Paraffin: GM2A Antibody [NBP3-00105] - Staining of human GM2A in human kidney with rabbit polyclonal antibody (1:5000).
Immunohistochemistry-Paraffin: GM2A Antibody [NBP3-00105]

Immunohistochemistry-Paraffin: GM2A Antibody [NBP3-00105]

Immunohistochemistry-Paraffin: GM2A Antibody [NBP3-00105] - Staining of human GM2A in human breast with rabbit polyclonal antibody (1:5000).

Applications for GM2A Antibody

Application
Recommended Usage

ELISA

1:5000-1:10000

Immunocytochemistry/ Immunofluorescence

1:300-1:10000

Immunohistochemistry

1:2500-1:10000

Formulation, Preparation, and Storage

Purification

Antigen and protein A Affinity-purified

Formulation

0.2 um filtered solution in PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GM2A

GM2A, also known as Ganglioside GM2 activator, is a 193 amino acid that is 21 kDa, with lysosome subcellular location, acts as s a lipid transfer protein that stimulates the enzymatic processing of gangliosides and T-cell activation; acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A which, together with this activator, catalyzes the degradation of the ganglioside GM2; also displays some calcium-independent phospholipase activity. Disease research on this protein has shown a relationship with tay-sachs disease, gangliosidosis, gangliosidosis gm2, sandhoff disease, neurological disorder, candidiasis, protein s deficiency, neurodegenerative disease, tay-sachs disease ab variant, spinal muscular atrophy, lysosomal storage disease, muscular atrophy, sinusitis, gastric cancer, cholesterol, and neuronitis. The GM2A protein has also shown an interaction with PLD2, GPLD1 and HEXA in the Sphingolipid metabolism, glycosphingolipid metabolism, lysosome, and phospholipid metabolism pathways.

Alternate Names

Cerebroside sulfate activator protein, ganglioside GM2 activator, GM2 ganglioside activator, GM2-AP, SAP-3GM2 ganglioside activator protein, Shingolipid activator protein 3, sphingolipid activator protein 3

Gene Symbol

GM2A

Additional GM2A Products

Product Documents for GM2A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GM2A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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