GnRHR Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-55419

Novus Biologicals, part of Bio-Techne
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NB100-55419
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all GnRHR Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-QKWTQKKEKGK corresponding to internal region according to NP_000397.1, NP_001012781.1.

Epitope

QKWTQKKEKGK

Specificity

This antibody is expected to recognise both reported isoforms (NP_000397.1; NP_001012781.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for GnRHR Antibody

Western Blot: GnRHR Antibody [NB100-55419]

Western Blot: GnRHR Antibody [NB100-55419]

Western Blot: GnRHR Antibody [NB100-55419] - (0.5ug/ml) staining of Human Peripheral Blood Mononucleocyte lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for GnRHR Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

0.5 - 1.5 ug/ml
Application Notes
WB: Approx. 60 kDa band observed in human lysates of peripheral blood mononucleocytes (calculated MW of 37.7 kDa band according to NP_000397.1). The observed molecular weight corresponds to earlier findings with different antibodies from other sources.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GnRHR

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.

Long Name

Gonadotropin-releasing Hormone Receptor

Alternate Names

GNRHR1, GRHR, HH7, LHRHR, LRHR, Luliberin

Entrez Gene IDs

2798 (Human)

Gene Symbol

GNRHR

UniProt

P30968 (Human)

Additional GnRHR Products

Product Documents for GnRHR Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GnRHR Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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