GP1BB Antibody (Gi27)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-89008

Clone Gi27 was used by HLDA to establish CD designation.
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # Gi27

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GP1BB Antibodies »

Product Summary for GP1BB Antibody (Gi27)

Immunogen

Human platelets.

Specificity

Recognizes the GPIbbeta- subunit (CD42c) of the GPIb/IX/V (CD42a/CD42b/CD42c/CD42d) complex.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for GP1BB Antibody (Gi27)

Application
Recommended Usage

Western Blot

1:20
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

N/A

Formulation

100ug of purified antibody in 200 ul PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GP1BB

Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alphachain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor(VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, andGPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling throughphosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated withBernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIbbeta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arisingfrom a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this producthas been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissuessuch as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signalwithin a separate gene (septin 5) located upstream of this gene. In the absence of polyadenylation from its ownimperfect site, the septin 5 gene uses the consensus polyA signal of this gene. (provided by RefSeq)

Long Name

Glycoprotein lb [Platelet] beta

Alternate Names

BDPLT1, CD42c, GPIb-Beta, GPIbb

Gene Symbol

GP1BB

Additional GP1BB Products

Product Documents for GP1BB Antibody (Gi27)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for GP1BB Antibody (Gi27)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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