GPR37 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS131

Novus Biologicals, part of Bio-Techne
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NLS131
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Primate (95%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all GPR37 Antibodies »

Product Specifications

Immunogen

Synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR37.

Epitope

N-Terminus extracellular domain

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (95%), Gibbon (95%), Marmoset (90%), Rabbit (85%).

Specificity

Human GPR37. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for GPR37 Antibody - BSA Free

Immunohistochemistry-Paraffin: GPR37 Antibody - BSA Free [NLS131]

Immunohistochemistry-Paraffin: GPR37 Antibody - BSA Free [NLS131]

Immunohistochemistry-Paraffin: GPR37 Antibody [NLS131] - Brain, Thalamus, neuron
Immunohistochemistry-Paraffin: GPR37 Antibody - BSA Free [NLS131]

Immunohistochemistry-Paraffin: GPR37 Antibody - BSA Free [NLS131]

Immunohistochemistry-Paraffin: GPR37 Antibody [NLS131] - Analysis of anti-GPR37 antibody with human brain, neurons and glia.
Immunohistochemistry-Paraffin: GPR37 Antibody - BSA Free [NLS131]

Immunohistochemistry-Paraffin: GPR37 Antibody - BSA Free [NLS131]

Immunohistochemistry-Paraffin: GPR37 Antibody [NLS131] - Anti-PAEL Receptor / GPR37 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Applications for GPR37 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

6 - 11 ug/ml
Application Notes
.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: GPR37

GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death. GPR37 expression has been reported in brain, liver, and placenta. ESTs have been isolated from brain, embryo, eye, fetal lung/testis/Bcell, gallbladder, heart, liver, liver/spleen, melanocyte/uterus/fetal heart, nerve, placenta, testis, tonsil, and vessel libraries.

Long Name

G Protein-coupled Receptor 37

Alternate Names

ETBR-LP-1, PAELR

Entrez Gene IDs

2861 (Human)

Gene Symbol

GPR37

Additional GPR37 Products

Product Documents for GPR37 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for GPR37 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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