Granulin Antibody (1F5)

Novus Biologicals, part of Bio-Techne | Catalog # H00002896-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Sandwich ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 1F5

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Granulin Antibodies »

Product Specifications

Immunogen

GRN (NP_002078, 494 a.a. ~ 593 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. SCEKEVVSAQPATFLARSPHVAVKDVECGEGHFCHDNQTCCRDNRQGWACCPYRQGVCCADRRHCCPAGFRCAARGTKCLRREAPRWDAPLRDPALRQLL

Specificity

GRN (1F5)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for Granulin Antibody (1F5)

Western Blot: Granulin Antibody (1F5) [H00002896-M01]

Western Blot: Granulin Antibody (1F5) [H00002896-M01]

Western Blot: Granulin Antibody (1F5) [H00002896-M01] - GRN monoclonal antibody (M01), clone 1F5 Analysis of GRN expression in HeLa.
Immunocytochemistry/ Immunofluorescence: Granulin Antibody (1F5) [H00002896-M01]

Immunocytochemistry/ Immunofluorescence: Granulin Antibody (1F5) [H00002896-M01]

Immunocytochemistry/Immunofluorescence: Granulin Antibody (1F5) [H00002896-M01] - Analysis of monoclonal antibody to GRN on HeLa cell. Antibody concentration 10 ug/ml.
Sandwich ELISA: Granulin Antibody (1F5) [H00002896-M01] - Detection limit for recombinant GST tagged GRN is approximately 1ng/ml as a capture antibody.

Applications for Granulin Antibody (1F5)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactivity against cell lysate for WB. It has been used for IF and ELISA.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Granulin

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Alternate Names

acrogranin, GEP, GP88, granulin, granulin-epithelin, granulins, PC cell-derived growth factor, PCDGF, PEPI, PGRN, Proepithelin, progranulin

Entrez Gene IDs

2896 (Human)

Gene Symbol

GRN

OMIM

138945 (Human)

UniProt

NP_002078 (Human)

Additional Granulin Products

Product Documents for Granulin Antibody (1F5)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Granulin Antibody (1F5)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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