Granulin Antibody (CL5695) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61425

Novus Biologicals, part of Bio-Techne
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NBP2-61425
NBP2-61425-25ul
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Key Product Details

Validated by

Knockout/Knockdown

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Knockout Validated, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL5695

Format

BSA Free

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Granulin Antibodies »

Product Specifications

Immunogen

This antibody was developed using a recombinant protein derived from P28799, with the exact immunogen sequence remaining proprietary.

Epitope

DHQHCCPQGYTCVAE

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Granulin Antibody (CL5695) - BSA Free

Western Blot: Granulin Antibody (CL5695) [NBP2-61425]

Western Blot: Granulin Antibody (CL5695) [NBP2-61425]

Western Blot: Granulin Antibody (CL5695) [NBP2-61425] - Analysis in human cell line PC-3.
Immunohistochemistry-Paraffin: Granulin Antibody (CL5695) [NBP2-61425]

Immunohistochemistry-Paraffin: Granulin Antibody (CL5695) [NBP2-61425]

Immunohistochemistry-Paraffin: Granulin Antibody (CL5695) [NBP2-61425] - Staining of human skeletal muscle shows absence of positivity in striated muscle fibers as expected (negative control).
Immunohistochemistry-Paraffin: Granulin Antibody (CL5695) [NBP2-61425]

Immunohistochemistry-Paraffin: Granulin Antibody (CL5695) [NBP2-61425]

Immunohistochemistry-Paraffin: Granulin Antibody (CL5695) [NBP2-61425] - Staining of human endometrium shows moderate granular cytoplasmic immunoreactivity in glandular cells.
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Applications for Granulin Antibody (CL5695) - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500

Western Blot

1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Granulin

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Alternate Names

acrogranin, GEP, GP88, granulin, granulin-epithelin, granulins, PC cell-derived growth factor, PCDGF, PEPI, PGRN, Proepithelin, progranulin

Gene Symbol

GRN

Additional Granulin Products

Product Documents for Granulin Antibody (CL5695) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Granulin Antibody (CL5695) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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