Granzyme B Antibody (CLB-GB11)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-50071

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Primate

Cited:

Human

Applications

Validated:

CyTOF-ready, Flow (Intracellular), Flow Cytometry

Cited:

CyTOF-ready, Flow Cytometry

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CLB-GB11

Concentration

1 mg/ml

View all Granzyme B Antibodies »

Product Specifications

Immunogen

Human NK cell line YT-INDY-derived granzyme B

Specificity

The mouse monoclonal antibody CLB-GB11 recognizes granzyme B, a 31 kDa serine protease expressed in activated Tc cells and NK cells.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

31 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Granzyme B Antibody (CLB-GB11)

Flow Cytometry: Granzyme B Antibody (CLB-GB11) [NBP1-50071]

Flow Cytometry: Granzyme B Antibody (CLB-GB11) [NBP1-50071]

Flow Cytometry: Granzyme B Antibody (CLB-GB11) [NBP1-50071] - Separation of Granzyme B positive lymphocytes (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (intracelluar staining) of human peripheral whole blood using anti-human Granzyme B (CLB-GB11) purified antibody (concentration in sample 3 ug/ml, GAM FITC).
Flow Cytometry: Granzyme B Antibody (CLB-GB11) [NBP1-50071]

Flow Cytometry: Granzyme B Antibody (CLB-GB11) [NBP1-50071]

Flow Cytometry: Granzyme B Antibody (CLB-GB11) [NBP1-50071] - Analysis of human CD8+ peripheral blood cells with anti-human granzyme B (CLB-GB11) PE.
Flow (Intracellular): Granzyme B Antibody (CLB-GB11) [NBP1-50071]

Flow (Intracellular): Granzyme B Antibody (CLB-GB11) [NBP1-50071]

Flow (Intracellular): Granzyme B Antibody (CLB-GB11) [NBP1-50071] - Flow cytometry intracellular staining pattern of human peripheral whole blood stained using anti-human Granzyme B (CLB-GB11) purified antibody (concentration in sample 3 ug/ml, GAM FITC).

Applications for Granzyme B Antibody (CLB-GB11)

Application
Recommended Usage

Flow (Intracellular)

1-4 ug/ml

Flow Cytometry

1-4 ug/ml
Application Notes
This antibody is Cytof ready.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

TBS (pH 8.0)

Preservative

0.9% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: Granzyme B

Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.

Alternate Names

CGL-1, CGL1, CSPB, CTLA-1, CTLA1, CTSGL1, Fragmentin-2, Granzyme-2, GRB, GrzB, GZMB, HLP, SECT

Gene Symbol

GZMB

Additional Granzyme B Products

Product Documents for Granzyme B Antibody (CLB-GB11)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Granzyme B Antibody (CLB-GB11)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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