HDAC7 [p Ser448] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-03979

Novus Biologicals, part of Bio-Techne
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NBP2-03979
NBP2-03979SS
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Key Product Details

Species Reactivity

Validated:

Human, Rat, Bovine, Canine, Equine, Primate

Predicted:

Mouse (90%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all HDAC7 Antibodies »

Product Summary for HDAC7 [p Ser448] Antibody

Immunogen

Within the range of amino acids 443-460 of human HDAC-7 protein were used as the immunogen ('b' represents a phosphorylated serine at position 448).

Epitope

CLSRAQbSPAA

Reactivity Notes

Reacts with Chimpanzee and New World Monkey. Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (90%).

Modification

p Ser448

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for HDAC7 [p Ser448] Antibody

Western Blot: HDAC7 [p Ser448] Antibody [NBP2-03979]

Western Blot: HDAC7 [p Ser448] Antibody [NBP2-03979]

Western Blot: HDAC7 [p Ser448] Antibody [NBP2-03979] - Analysis of phosphorylated HDAC-7 in (A) recombinant fusion protein containing Ser448 and (B) fusion protein without the phosphorylated amino acid, using this antibody at 1 ug/ml.

Applications for HDAC7 [p Ser448] Antibody

Application
Recommended Usage

Western Blot

0.1-0.5 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

0.1 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HDAC7

Histone deacetylase 7 is a thymus-specific, intracellular transcription factor belonging to the class IIa histone deacetylase family. Reports suggest that dephosphorylation and nuclear localization of HDAC-7 is promoted by Myosin phosphatase, thus regulating the repression of Nur77 and inhibition of apoptosis in CD4+CD8+ double-positive thymocytes. HDAC-7 plays a specific role in maintaining vascular integrity by repressing the expression of matrix metalloproteinase (MMP) 10. It promotes repression mediated by transcriptional corepressor NCOR2 and is an efficient corepressor of the androgen receptor (AR). It is also responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4).

Long Name

Histone deacetylase 7

Alternate Names

HD7, HD7a, HDAC7A

Gene Symbol

HDAC7

UniProt

NP_055522 (Human)

Additional HDAC7 Products

Product Documents for HDAC7 [p Ser448] Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for HDAC7 [p Ser448] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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