Histone Deacetylase 8/HDAC8 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-14085

Novus Biologicals, part of Bio-Techne
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NBP2-14085
NBP2-14085-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Cited:

Human

Predicted:

Mouse (99%), Rat (99%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Histone Deacetylase 8/HDAC8 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to the amino acids: VLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEF

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Histone Deacetylase 8/HDAC8 Antibody

Immunohistochemistry-Paraffin: Histone Deacetylase 8/HDAC8 Antibody [NBP2-14085]

Immunohistochemistry-Paraffin: Histone Deacetylase 8/HDAC8 Antibody [NBP2-14085]

Immunohistochemistry-Paraffin: Histone Deacetylase 8/HDAC8 Antibody [NBP2-14085] - Analysis in human thyroid gland and skeletal muscle tissues. Corresponding HDAC8 RNA-seq data are presented for the same tissues.
Immunocytochemistry/ Immunofluorescence: Histone Deacetylase 8/HDAC8 Antibody [NBP2-14085]

Immunocytochemistry/ Immunofluorescence: Histone Deacetylase 8/HDAC8 Antibody [NBP2-14085]

Immunocytochemistry/Immunofluorescence: Histone Deacetylase 8/HDAC8 Antibody [NBP2-14085] - Staining of human cell line PC-3 shows localization to nucleus & plasma membrane. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Histone Deacetylase 8/HDAC8 Antibody [NBP2-14085]

Immunohistochemistry-Paraffin: Histone Deacetylase 8/HDAC8 Antibody [NBP2-14085]

Immunohistochemistry-Paraffin: Histone Deacetylase 8/HDAC8 Antibody [NBP2-14085] - Staining of human rectum shows moderate to strong nuclear positivity in glandular cells, as well as in lymphoid cells.
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Applications for Histone Deacetylase 8/HDAC8 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Histone Deacetylase 8/HDAC8

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.

Alternate Names

HDAC8, HDACL1, RPD3

Gene Symbol

HDAC8

Additional Histone Deacetylase 8/HDAC8 Products

Product Documents for Histone Deacetylase 8/HDAC8 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Histone Deacetylase 8/HDAC8 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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