HLA DOB Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00003112-D01P

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all HLA DOB Antibodies »

Product Specifications

Immunogen

HLA-DOB (NP_002111.1, 1 a.a. - 273 a.a.) full-length human protein. MGSGWVPWVVALLVNLTRLDSSMTQGTDSPEDFVIQAKADCYFTNGTEKVQFVVRFIFNLEEYVRFDSDVGMFVALTKLGQPDAEQWNSRLDLLERSRQAVDGVCRHNYRLGAPFTVGRKVQPEVTVYPERTPLLHQHNLLHCSVTGFYPGDIKIKWFLNGQEERAGVMSTGPIRNGDWTFQTVVMLEMTPELGHVYTCLVDHSSLLSPVSVEWRAQSEYSWRKMLSGIAAFLLGLIFLLVGIVIQLRAQKGYVRTQMSGNEVSRAVLLPQSC

Specificity

Reacts with major histocompatibility complex, class II, DO beta.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Quality control test: Antibody reactive against mammalian transfected lysate.

Scientific Data Images for HLA DOB Antibody

Western Blot: HLA DOB Antibody [H00003112-D01P]

Western Blot: HLA DOB Antibody [H00003112-D01P]

Western Blot: HLA DOB Antibody [H00003112-D01P] - Analysis of HLA-DOB expression in human placenta.
Western Blot: HLA DOB Antibody [H00003112-D01P]

Western Blot: HLA DOB Antibody [H00003112-D01P]

Western Blot: HLA DOB Antibody [H00003112-D01P] - Analysis of HLA-DOB expression in transfected 293T cell line by HLA-DOB polyclonal antibody.Lane 1: HLA-DOB transfected lysate(30.80 KDa).Lane 2: Non-transfected lysate.

Applications for HLA DOB Antibody

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
This antibody is reactive against tissue and transfected lysate in WB and as a detection antibody in ELISA.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: HLA DOB

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq]

Alternate Names

DOB, FLJ57033, HLA class II histocompatibility antigen, DO beta chain, major histocompatibility complex, class II, DO beta, MHC class II antigen DOB

Entrez Gene IDs

3112 (Human)

Gene Symbol

HLA-DOB

UniProt

NP_002111.1 (Human)

Additional HLA DOB Products

Product Documents for HLA DOB Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for HLA DOB Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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