HLA DOB Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87469

Novus Biologicals, part of Bio-Techne
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NBP1-87469
NBP1-87469-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Immunohistochemistry

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all HLA DOB Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: KADCYFTNGTEKVQFVVRFIFNLEEYVRFDSDVGMFVALIKLGQPDAEQWNSRLDLLERSRQAVDGVCRHNYRLGAPFTVGRKVQPEVTVYPERTPLLHQHNLLHCSVTGFYPGDIKIKWFLNGQEERAGVMSTGPIRNGD

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for HLA DOB Antibody

Immunohistochemistry-Paraffin: HLA DOB Antibody [NBP1-87469]

Immunohistochemistry-Paraffin: HLA DOB Antibody [NBP1-87469]

Immunohistochemistry-Paraffin: HLA DOB Antibody [NBP1-87469] - Staining in human tonsil and cerebral cortex tissues using anti-HLA-DOB antibody. Corresponding HLA-DOB RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: HLA DOB Antibody [NBP1-87469]

Immunohistochemistry-Paraffin: HLA DOB Antibody [NBP1-87469]

Immunohistochemistry-Paraffin: HLA DOB Antibody [NBP1-87469] - Staining of human tonsil shows high expression.
Immunohistochemistry-Paraffin: HLA DOB Antibody [NBP1-87469]

Immunohistochemistry-Paraffin: HLA DOB Antibody [NBP1-87469]

Immunohistochemistry-Paraffin: HLA DOB Antibody [NBP1-87469] - Staining of human cerebral cortex shows low expression as expected.

Applications for HLA DOB Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HLA DOB

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq]

Alternate Names

DOB, FLJ57033, HLA class II histocompatibility antigen, DO beta chain, major histocompatibility complex, class II, DO beta, MHC class II antigen DOB

Gene Symbol

HLA-DOB

Additional HLA DOB Products

Product Documents for HLA DOB Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for HLA DOB Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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