HLA DQ1/DQ3 Antibody (HL-37) [mFluor Violet 450 SE]

Novus Biologicals, part of Bio-Techne | Catalog # NB500-405MFV450

Novus Biologicals, part of Bio-Techne
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NB500-405MFV450
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NB500-405
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Key Product Details

Species Reactivity

Human, Porcine

Applications

CyTOF-ready, Flow Cytometry, Immunoprecipitation, Western Blot

Label

mFluor Violet 450 SE (Excitation = 406 nm, Emission = 445 nm)

Antibody Source

Monoclonal Mouse IgG3 Clone # HL-37

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all HLA DQ1/DQ3 Antibodies »

Product Specifications

Immunogen

Burkitt's lymphoma cell line Raji

Specificity

The antibody HL-37 reacts with polymorphic determinant on human HLA-DQ1 and HLA-DQ3 molecules (recognized epitope was found on isolated beta chain of DQ1), but does not react with HLA-DQ2. DQ is the isotype of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG3

Scientific Data Images for HLA DQ1/DQ3 Antibody (HL-37) [mFluor Violet 450 SE]

HLA DQ1/DQ3 Antibody (HL-37) [mFluor Violet 450 SE] [NB500-405MFV450] -

HLA DQ1/DQ3 Antibody (HL-37) [mFluor Violet 450 SE] [NB500-405MFV450] - Vial of mFluor Violet 450 conjugated antibody. mFluor Violet 450 is optimally excited at 406 nm by the Violet laser (405 nm) and has an emission maximum of 445 nm.

Applications for HLA DQ1/DQ3 Antibody (HL-37) [mFluor Violet 450 SE]

Application
Recommended Usage

CyTOF-ready

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: HLA DQ1/DQ3

HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of analpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells(APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons.Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes thetransmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the betachain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 differentmolecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. (provided by RefSeq)

Alternate Names

CELIAC1, HLA class II histocompatibility antigen, DQ beta 1 chain, HLA-DQB, IDDM1, MHC class II antigen DQB1, MHC class II antigen HLA-DQ-beta-1, MHC class II DQ beta chain, MHC class II HLA-DQ beta glycoprotein

Gene Symbol

HLA-DQA1

Additional HLA DQ1/DQ3 Products

Product Documents for HLA DQ1/DQ3 Antibody (HL-37) [mFluor Violet 450 SE]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for HLA DQ1/DQ3 Antibody (HL-37) [mFluor Violet 450 SE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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