HLA DQ1/DQ3 Antibody (HL-37) [PE/Cy7]

Novus Biologicals, part of Bio-Techne | Catalog # NB500-405PECY7

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human, Porcine

Applications

Flow Cytometry

Label

PE/Cy7 (Excitation = 488 nm, Emission = 778 nm)

Antibody Source

Monoclonal Mouse IgG3 Clone # HL-37

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all HLA DQ1/DQ3 Antibodies »

Product Specifications

Immunogen

Burkitt's lymphoma cell line Raji

Reactivity Notes

Cross-reacts with Human.

Specificity

The antibody HL-37 reacts with polymorphic determinant on human HLA-DQ1 and HLA-DQ3 molecules (recognized epitope was found on isolated beta chain of DQ1), but does not react with HLA-DQ2. DQ is the isotype of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG3

Applications for HLA DQ1/DQ3 Antibody (HL-37) [PE/Cy7]

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined. For optimal results using our Tandem dyes, please avoid prolonged exposure to light or extreme temperature fluctuations. These can lead to irreversible degradation or decoupling. When staining intracellular targets, specific attention to the fixation and permeabilization steps in your flow protocol may be required. Please contact our technical support team at technical@novusbio.com if you have any questions.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark. Do not freeze.

Background: HLA DQ1/DQ3

HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of analpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells(APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons.Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes thetransmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the betachain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 differentmolecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. (provided by RefSeq)

Alternate Names

CELIAC1, HLA class II histocompatibility antigen, DQ beta 1 chain, HLA-DQB, IDDM1, MHC class II antigen DQB1, MHC class II antigen HLA-DQ-beta-1, MHC class II DQ beta chain, MHC class II HLA-DQ beta glycoprotein

Gene Symbol

HLA-DQA1

Additional HLA DQ1/DQ3 Products

Product Documents for HLA DQ1/DQ3 Antibody (HL-37) [PE/Cy7]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for HLA DQ1/DQ3 Antibody (HL-37) [PE/Cy7]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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