HMGN2 Antibody (SR1289)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-22315

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-22315-100ul
NBP3-22315-50ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1289

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all HMGN2 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human HMGN2 (Uniprot #: P05204)

Specificity

Detects endogenous levels of total HMGN2

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

18 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for HMGN2 Antibody (SR1289)

Western Blot: HMGN2 Antibody (SR1289) [NBP3-22315] -

Western Blot: HMGN2 Antibody (SR1289) [NBP3-22315] - Western blot analysis using NBP3-22315 in K562 cell lysate.

Applications for HMGN2 Antibody (SR1289)

Application
Recommended Usage

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HMGN2

HMG17 (high mobility group transcription factor 17) is an 18 kD high mobility group chromosomal protein. This nuclear protein is common to all eukaryotes and is developmentally regulated. HMG17 binds DNA in a non-sequence specific manner and interacts with nucleosomes to modulate chromatin structure. HMG17 regulates the gene expression of p53, Hox transcription factors, and steroid hormone receptors (increases DNA binding affinity). Phosphorylation of HMG17 may interfere with nuclear localization and favor release from nuclei. HMG17 is upregulated by wild-type p53 and increases during embryogenesis and is downregulated during differentiation and development. This protein is modified by phosphorylation and acetylation. HMG17 interacts with nucleosomes and probably forms multi-unit complexes with unrelated proteins. The Poly6081 antibody recognizes human and mouse HMG17 and has been shown to be useful for Western blotting.

Alternate Names

High mobility group nucleosome-binding domain-containing protein 2, high-mobility group (nonhistone chromosomal) protein 17, high-mobility group nucleosomal binding domain 2, HMG17high mobility group protein N2, MGC5629, MGC88718, non-histone chromosomal protein HMG-17, nonhistone chromosomal protein HMG-17

Gene Symbol

HMGN2

Additional HMGN2 Products

Product Documents for HMGN2 Antibody (SR1289)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for HMGN2 Antibody (SR1289)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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