HOIP/RNF31 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27290

Novus Biologicals, part of Bio-Techne
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NBP2-27290SS
NBP2-27290
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Chimpanzee (94%), Orangutan (94%), Rhesus Macaque (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all HOIP/RNF31 Antibodies »

Product Specifications

Immunogen

A portion of amino acids 950-1000 from human RNF31 (HOIP) was used as the immunogen for this antibody. NP-060469.4

Reactivity Notes

The amino acid sequence used as immunogen for this antibody is 94% homologous in Crab-eating Macaque, White-cheeked Gibbon, 88% in Guinea pig, Canine, common Rabbit, and Porcine, 82% in Chinese Hamster, gray short-tailed Opossum, Rat, and Xenopus.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for HOIP/RNF31 Antibody

Immunohistochemistry: HOIP/RNF31 Antibody [NBP2-27290]

Immunohistochemistry: HOIP/RNF31 Antibody [NBP2-27290]

Immunohistochemistry: HOIP/RNF31 Antibody [NBP2-27290] - Analysis of RNF31 (HOIP) using RNF31 antibody. Human rectum probed with RNF31 antibody at 5 ug/ml.

Applications for HOIP/RNF31 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HOIP/RNF31

RNF31, ring finger protein 31, is an E3 ubiquitin ligase also known as ZIBRA and HOIP is 110-120kDa. There are a number of functions attributed to RNF31 (HOIP) including zinc-ion binding and protein-poly ubiquitination (1-3). The NF-kB pathway is positively regulated by RNF31. T cell activation through T cell receptors is also modulated through RNF31. Based on its monoubiquitination of DAX-1, a mammalian orphan receptor associated with steroidogenesis, RNF31 (HOIP) also appears to be a requisite co-regulator of steroidogenic pathways (4).

Long Name

HOIL-1-Interacting Protein

Alternate Names

RNF31, ZIBRA

Gene Symbol

RNF31

Additional HOIP/RNF31 Products

Product Documents for HOIP/RNF31 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for HOIP/RNF31 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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