HRD1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-89667

Novus Biologicals, part of Bio-Techne
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NBP1-89667
NBP1-89667-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Validated:

Human

Predicted:

Mouse (92%), Rat (90%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all HRD1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: PAPGFPFPPPWMGMPLPPPFAFPPMPVPPAGFAGLTPEELRALEGHERQHLEARLQSLRNIHTLLDAAMLQINQYLTVLASLGPPRPATSVNSTEETATTVVAAASSTSIPSSEATTPTPGASPPAPEMERPPAPESVGT

Reactivity Notes

Reactivity reported in scientific literature (PMID: 23435261)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for HRD1 Antibody

Immunocytochemistry/ Immunofluorescence: HRD1 Antibody [NBP1-89667]

Immunocytochemistry/ Immunofluorescence: HRD1 Antibody [NBP1-89667]

Immunocytochemistry/Immunofluorescence: HRD1 Antibody [NBP1-89667] - Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & endoplasmic reticulum.
Immunohistochemistry-Paraffin: HRD1 Antibody [NBP1-89667]

Immunohistochemistry-Paraffin: HRD1 Antibody [NBP1-89667]

Immunohistochemistry-Paraffin: HRD1 Antibody [NBP1-89667] - Staining of human lymph node.
Immunohistochemistry-Paraffin: HRD1 Antibody [NBP1-89667]

Immunohistochemistry-Paraffin: HRD1 Antibody [NBP1-89667]

Immunohistochemistry-Paraffin: HRD1 Antibody [NBP1-89667] - Staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells
View 5 more images

Applications for HRD1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HRD1

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.

Alternate Names

E3 ubiquitin-protein ligase synoviolin, EC 6.3.2, HRD1EC 6.3.2.-, KIAA1810Synovial apoptosis inhibitor 1, MGC40372, synovial apoptosis inhibitor 1, synoviolin

Gene Symbol

SYVN1

Additional HRD1 Products

Product Documents for HRD1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for HRD1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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