HRD1 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-02998

Novus Biologicals, part of Bio-Techne
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NBP3-02998-100ul
NBP3-02998-20ul
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all HRD1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 500-600 of human HRD1 (NP_757385.1). LEARLQSLRNIHTLLDAAMLQINQYLTVLASLGPPRPATSVNSTEETATTVVAAASSTSIPSSEATTPTPGASPPAPEMERPPAPESVGTEEMPEDGEPDA

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for HRD1 Antibody - BSA Free

Western Blot: HRD1 AntibodyBSA Free [NBP3-02998]

Western Blot: HRD1 AntibodyBSA Free [NBP3-02998]

Western Blot: HRD1 Antibody [NBP3-02998] - Analysis of extracts of various cell lines, using HRD1 antibody at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection:Basic ECL Kit

Applications for HRD1 Antibody - BSA Free

Application
Recommended Usage

Western Blot

1:500 -1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS with 50% glycerol, pH7.3.

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: HRD1

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.

Alternate Names

E3 ubiquitin-protein ligase synoviolin, EC 6.3.2, HRD1EC 6.3.2.-, KIAA1810Synovial apoptosis inhibitor 1, MGC40372, synovial apoptosis inhibitor 1, synoviolin

Gene Symbol

SYVN1

Additional HRD1 Products

Product Documents for HRD1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for HRD1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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