HSD17B8 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-84309

Novus Biologicals, part of Bio-Techne
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NBP1-84309
NBP1-84309-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (90%), Rat (90%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all HSD17B8 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: GQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGY

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for HSD17B8 Antibody

Western Blot: HSD17B8 Antibody [NBP1-84309]

Western Blot: HSD17B8 Antibody [NBP1-84309]

Western Blot: HSD17B8 Antibody [NBP1-84309] - Analysis in control (vector only transfected HEK293T lysate) and HSD17B8 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).
Immunohistochemistry-Paraffin: HSD17B8 Antibody [NBP1-84309]

Immunohistochemistry-Paraffin: HSD17B8 Antibody [NBP1-84309]

Immunohistochemistry-Paraffin: HSD17B8 Antibody [NBP1-84309] - Staining in human parathyroid gland and testis tissues using anti-HSD17B8 antibody. Corresponding HSD17B8 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: HSD17B8 Antibody [NBP1-84309]

Immunohistochemistry-Paraffin: HSD17B8 Antibody [NBP1-84309]

Immunohistochemistry-Paraffin: HSD17B8 Antibody [NBP1-84309] - Staining of human kidney shows strong cytoplasmic positivity in cells in tubules.
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Applications for HSD17B8 Antibody

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HSD17B8

In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq]

Alternate Names

D6S2245EdJ1033B10.9, EC 1.1.1.-, EC 1.1.1.62, EC 1.1.1.63,17-beta-HSD 8, estrogen 17-oxidoreductase, FABGLestradiol 17-beta-dehydrogenase 8, H2-KE6, HKE6FabG (beta-ketoacyl-[acyl-carrier-protein] reductase, E coli) like (E. coli), hydroxysteroid (17-beta) dehydrogenase 8,3-oxoacyl-[acyl-carrier-protein] reductase, KE6, ke-6, Ke-6,17-beta-hydroxysteroid dehydrogenase 8, Protein Ke6, Really interesting new gene 2 protein, RING2FABG, SDR30C1, short chain dehydrogenase/reductase family 30C, member 1, Testosterone 17-beta-dehydrogenase 8

Gene Symbol

HSD17B8

Additional HSD17B8 Products

Product Documents for HSD17B8 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for HSD17B8 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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