HSP90 Antibody (16F1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-97506

Novus Biologicals, part of Bio-Techne
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NBP1-97506-0.025mg
NBP1-97506-0.05mg
NBP1-97506-0.2mg
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine, Bovine, Canine, Chicken, Drosophila, Fish, Guinea Pig, Invertebrate, Mammal, Opossum, Plant, Primate, Rabbit, Sheep, Xenopus

Cited:

Human, Mouse

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2A Clone # 16F1

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all HSP90 Antibodies »

Product Specifications

Immunogen

Native human Hsp90.

Reactivity Notes

Opossum, Mussel, Beluga

Clonality

Monoclonal

Host

Rat

Isotype

IgG2A

Scientific Data Images for HSP90 Antibody (16F1)

Western Blot: HSP90 Antibody (16F1) [NBP1-97506]

Western Blot: HSP90 Antibody (16F1) [NBP1-97506]

Western Blot: HSP90 Antibody (16F1) [NBP1-97506] - Lane 1: MW marker, Lane 2: HSP90 native protein, Lane 3: HSP90b recombinant protein, Lane 4: HSP90alpha recombinant protein, Lane 5: HeLa (HS), Lane 6: L-929 (HS), Lane 7: Rat-2 (HS), Lane 8:RK-13 (HS).
Immunohistochemistry-Paraffin: HSP90 Antibody (16F1) [NBP1-97506]

Immunohistochemistry-Paraffin: HSP90 Antibody (16F1) [NBP1-97506]

Immunohistochemistry-Paraffin: HSP90 Antibody (16F1) [NBP1-97506] - Analysis of human spleen tissue stained with HSP90, mAb (16F1) at 10ug/ml.

Applications for HSP90 Antibody (16F1)

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Immunoprecipitation

1:10-1:500

Western Blot

1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS (pH 7.2) and 50% Glycerol

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: HSP90

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

Long Name

Heat Shock Protein 90

Alternate Names

FLJ31884, Heat shock 86 kDa, heat shock 90kD protein 1, alpha, heat shock 90kD protein 1, alpha-like 4, heat shock 90kD protein, alpha-like 4, heat shock 90kDa protein 1, alpha, heat shock protein 90kDa alpha (cytosolic), class A member 1, heat shock protein HSP 90-alpha, Hsp89, Hsp90, HSP90AHSP86, HSP90N, HSPC1HSP 86, HSPCAHSP89A, HSPCAL1, HSPCAL4, HSPN, LAP2, Renal carcinoma antigen NY-REN-38

Gene Symbol

HSP90AA1

Additional HSP90 Products

Product Documents for HSP90 Antibody (16F1)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for HSP90 Antibody (16F1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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