Human alpha-Taxilin Antibody

alpha‑Taxilin (TXLN‑ alpha; also p75 [in rat] and IL‑14 alpha) is the founding member of the taxilin family of proteins. Although its predicted MW is 62 kDa, it runs anomalously at 74‑76 kDa in SDS‑PAGE. alpha‑Taxilin is ubiquitously expressed and participates in intracellular vesicle trafficking. In particular, alpha‑Taxilin interacts with syntaxin family members that localize to the plasma membrane, providing for SNARE complex formation. alpha‑Taxilin also regulates the placement of growing protein chains. Human alpha‑Taxilin is 546 amino acids (aa) in length. Its defining characteristic is a large coiled‑coil region between aa 186‑491. When an alternate start site at Met176 is used, a secreted cytokine is generated termed IL‑14 alpha. Over aa 1‑162, human alpha‑Taxilin shares 81% aa identity with mouse alpha‑Taxilin.