Human beta-2 Adrenergic R/ADRB2 Antibody
R&D Systems, part of Bio-Techne | Catalog # MAB100401
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
CyTOF-ready, Flow Cytometry
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG1 Clone # 586107
Product Specifications
Immunogen
NS0 mouse myeloma cell line transfected with human beta‑2 Adrenergic R/ADRB2
Accession # P07550
Accession # P07550
Specificity
Detects human beta‑2 Adrenergic R/ADRB2 in direct ELISAs.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Applications for Human beta-2 Adrenergic R/ADRB2 Antibody
Application
Recommended Usage
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
Flow Cytometry
0.25 µg/106 cells
Sample: HEK293 Human Cell Line Transfected with Human beta-2 Adrenergic R/ADRB2 and eGFP
Sample: HEK293 Human Cell Line Transfected with Human beta-2 Adrenergic R/ADRB2 and eGFP
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: beta-2 Adrenergic R/ADRB2
Beta-2 adrenoceptor (ADRB2) is a 413 amino acids adrenergic receptor expressed in smooth muscle and metabolic tissues. Beta-adrenergic receptors belong to the seven-transmembrane domain/GPCR family of receptors and mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Activation of ADRB2 induces a decrease in gastrointestinal motility, bronchodilation, vasodilation in skeletal and cardiac muscle, and glycogenolysis in liver. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src, the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1). Expression of the beta-2 adrenoceptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel.
Long Name
Beta-2 Adrenergic Receptor
Alternate Names
ADRB2, ADRB2R, B2AR, beta-2 AdrenergicR, beta2 AdrenergicR
Gene Symbol
ADRB2
UniProt
Additional beta-2 Adrenergic R/ADRB2 Products
Product Documents for Human beta-2 Adrenergic R/ADRB2 Antibody
Product Specific Notices for Human beta-2 Adrenergic R/ADRB2 Antibody
For research use only
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