Human C1qR1/CD93 Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB23791

R&D Systems, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human, Mouse

Applications

Validated:

CyTOF-ready, Flow Cytometry, Western Blot

Cited:

ELISA (Capture), ELISA Development (Capture)

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 273107

View all C1qR1/CD93 Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human C1q R1/CD93
Ala24-Lys580
Accession # Q9NPY3

Specificity

Detects human C1q R1/CD93 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant mouse C1q R1 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Human C1qR1/CD93 Antibody

Application
Recommended Usage

CyTOF-ready

Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.

Flow Cytometry

2.5 µg/106 cells
Sample: Human whole blood monocytes

Western Blot

1 µg/mL
Sample: Recombinant Human C1q R1/CD93 under non-reducing conditions only
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
Size / Price
Qty

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: C1qR1/CD93

C1q R1 is also known as C1q Rp, Collectin Receptor, and AA4 antigen, and is designated CD93. C1q R1 mediates enhanced phagocytosis by monocytes and macrophages upon interaction with soluble defense collagens including C1q, MBL, and SP-A (1, 2). It is a type I transmembrane glycoprotein expressed on endothelial cells, hematopoietic progenitor cells, platelets, and cells of myeloid origin. C1q R1 has also been identified as a stem cell marker (3, 4).

References

  1. Kim, T.S. et al. (2000) Mol. Immunol. 37:377.
  2. Dean, Y.D. et al. (2001) Eur. J. Immunol. 31:1370.
  3. Petrenko, O. et al. (1999) Immunity 10:691.
  4. Danet, G.H. et al. (2002) Proc. Natl. Acad. Sci. USA 99:10441.

Long Name

Complement Component C1q Receptor

Alternate Names

AA4 Antigen, C1q R1, C1q Rp, C1qRp, CD93, Collectin Receptor, Ly68

Entrez Gene IDs

22918 (Human); 17064 (Mouse); 84398 (Rat)

Gene Symbol

CD93

UniProt

Q9NPY3

Additional C1qR1/CD93 Products

Product Documents for Human C1qR1/CD93 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human C1qR1/CD93 Antibody

For research use only

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