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Human Complement Component C1rLP Antibody

R&D Systems, part of Bio-Techne | Catalog # AF3676

R&D Systems, part of Bio-Techne
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AF3676
AF3676-SP

Key Product Details

Species Reactivity

Human

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Complement Component C1rLP
Ser41-Asn487
Accession # AAI56781

Specificity

Detects human Complement Component C1rLP in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant mouse C1rLP is observed and less than 5% cross-reactivity with recombinant human (rh) C1R, rhC1S, and rhMASP-3 is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human Complement Component C1rLP Antibody

Application
Recommended Usage

Immunoprecipitation

25 µg/mL
Sample: Conditioned cell culture medium spiked with Recombinant Human Complement Component C1rLP, see our available Western blot detection antibodies

Western Blot

0.1 µg/mL
Sample: Recombinant Human Complement Component C1rLP

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Complement Component C1rLP

C1rLP, also known as CLSPa, is a plasma serine protease that is related to the C1r complement component. C1rLP is a 487 amino acid protein that contains one CUB domain and a serine protease domain. C1rLP activates pro-C1s and pro-haptoglobin but also inhibits complement-mediated cytotoxicity. Human and mouse C1rLP share 73% aa sequence identity.

Long Name

Complement C1r Subcomponent-like Protein

Alternate Names

C1RL, C1RL1, CLSPa

Entrez Gene IDs

51279 (Human); 232371 (Mouse)

Gene Symbol

C1RL

UniProt

Additional Complement Component C1rLP Products

Product Documents for Human Complement Component C1rLP Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human Complement Component C1rLP Antibody

For research use only

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