Human Cubilin Biotinylated Antibody
R&D Systems, part of Bio-Techne | Catalog # BAF3700
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Biotin
Antibody Source
Polyclonal Sheep IgG
Product Specifications
Immunogen
E. coli-derived recombinant human Cubilin
Ser36-Gly126
Accession # O60494
Ser36-Gly126
Accession # O60494
Specificity
Detects human Cubilin in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human (rh) Notch-2 and rhNotch-3 is observed.
Clonality
Polyclonal
Host
Sheep
Isotype
IgG
Applications for Human Cubilin Biotinylated Antibody
Application
Recommended Usage
Western Blot
0.1 µg/mL
Sample: Recombinant Human Cubilin
Sample: Recombinant Human Cubilin
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Cubilin
Cubilin is a 460 kDa protein that is a component of a multiligand endocytic receptor complex, which also contains amnionless, megalin and LRP2. The receptor complex is expressed in several absorptive epithelia, including kidney proximal tubule, yolk sac, and the small intestine. Human Cubilin is synthesized as a 3623 residue precursor with a signal peptide, an amino-terminal domain, eight EGF-like repeats and 27 Cub domains. Co-expression with amnionless is required for the membrane anchoring, ER export and internalizing action of Cubilin. Within the region used as the immunogen, human, mouse and rat Cubilin share approximately 76% amino acid sequence homology.
Alternate Names
CUBN, Cubulin, gp280, IFCR, MGA1
Gene Symbol
CUBN
UniProt
Additional Cubilin Products
Product Documents for Human Cubilin Biotinylated Antibody
Product Specific Notices for Human Cubilin Biotinylated Antibody
For research use only
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