Human CXCL10/IP-10/CRG-2 Antibody

R&D Systems, part of Bio-Techne | Catalog # AB-266-PB

R&D Systems, part of Bio-Techne
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AB-266-PB
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

View all CXCL10/IP-10/CRG-2 Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human CXCL10/IP-10

Specificity

Detects human CXCL-10/IP-10/CRG-2 in direct ELISAs and Western blots. In direct ELISAs, this antibody shows less than 1% cross‑reactivity with rhENA-78, rhGRO alpha, rhGRO beta, rhGRO gamma, rhI‑309, rmJE, rhMCP-1, rhMIP‑1 alpha, rmMIP‑1 alpha, rhMIP-1 beta, rmMIP-1 beta, and rhRANTES.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human CXCL10/IP-10/CRG-2 Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Human CXCL10/IP-10/CRG-2 (Catalog # 266-IP)

Reviewed Applications

Read 1 review rated 5 using AB-266-PB in the following applications:

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Reconstitution

Reconstitute at 1 mg/mL in sterile PBS.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CXCL10/IP-10/CRG-2

CXCL10 was originally identified as an IFN-gamma -inducible gene in monocytes, fibroblasts and endothelial cells. It has since been shown that CXCL10 mRNA is also induced by LPS, IL-1 beta, TNF-alpha, IL-12 and viruses. Additional cell types that have been shown to express CXCL10 include activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells. CXCL10 is also expressed in psoriatic and lepromatous lesions of skin. The mouse homologue of human CXCL10, Crg-2, has been cloned and shown to share approximately 67% amino acid sequence identity with human CXCL10. Human CXCL10 cDNA encodes a 98 amino acid (aa) residue precursor protein with a 21 aa residue signal peptide that is cleaved to form the 77 aa residue secreted protein. The amino acid sequence of CXCL10 identified the protein as a member of the chemokine alpha subfamily that lacks the ELR domain. CXCL10 has been shown to be a chemoattractant for activated T-lymphocytes. CXCL10 has been reported to be a potent inhibitor of angiogenesis and to display a potent thymus-dependent antitumor effect. A chemokine receptor specific for CXCL10 and Mig has been cloned and shown to be highly expressed in IL-2-activated T-lymphocytes.

References

  1. Loetscher, M. et al. (1996) J. Exp. Med. 184:963.
  2. Wang, X. et al .(1996) J. Biol. Chem. 271:24286.

Alternate Names

CRG-2, CRG2, IP-10

Entrez Gene IDs

3627 (Human); 15945 (Mouse)

Gene Symbol

CXCL10

Additional CXCL10/IP-10/CRG-2 Products

Product Documents for Human CXCL10/IP-10/CRG-2 Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human CXCL10/IP-10/CRG-2 Antibody

For research use only

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